November 17, 1995
=================

The GENESIS distribution has been updated to version 2.0.1, which includes a
number of bug fixes, new features (described in genesis/src/CHANGES), and
support for the Kinetikit.

Kinetikit is a utility for modeling large numbers of chemical reactions such
as occur in biochemical signaling pathways. It consists of two sections: the
C-code library kinetics, which gets compiled and linked with GENESIS, and
the script interface for kinetikit, also known as kkit.  Kkit is designed to
provide a user-friendly, click-and drag interface for kinetics modeling. In
addition to defining and running kinetic models, it is intended to
facilitate managing kinetic data in models of complex signaling pathways.

The files are contained in:
Kkit1.1.tar.Z - the C-code library and kkit.

kkit.bin.tar - GENESIS binaries compiled with the kinetics library for
    various platforms (currently Solaris, Linux and SGI). (optional)

An updated version of the parallel GENESIS libraries, with support for the
Cray T3D, is contained in the file pargenesis.R1P1.tar.Z, which replaces
pargenesis.R1.tar.Z.  The patches themselves are available in
pargenesis.R1.patch1.Z.

European ftp site for GENESIS: You may now get the GENESIS 2.0 distribution,
as well as Kinetikit and the libraries for Parallel GENESIS by anonymous ftp
from ftp://bbf-ftp.uia.ac.be/genesis.

September 6, 1995
=================

For the convenience of of those with slow or unreliable ftp connections or
who wish to transfer them to MSDOS format floppies (e.g.  with mtools, SUN's
PCFS, or with Linux), we have provided an alternate form of the GENESIS 2.0
distribution.  The following two files have the same contents as
genesis.tar.Z, but are more efficiently compressed.

     size   name           description
     ====   ====           =========== 
   1237725  gendisk1.tgz - the genesis directory tree, without Doc and Scripts
    879296  gendisk2.tgz - genesis/Doc and genesis/Scripts

After being transfered to a UNIX system, they should be renamed to
gendisk1.tar.gz and gendisk2.tar.gz and uncompressed with the gnu "gunzip"
utility, then extracted with tar.  This can be done with:

    gunzip -c gendisk1.tar.gz | tar xvf -

On most Linux systems, it is possible to simply use:

    zcat gendisk1.tgz | tar xvf -

Note that these *cannot* be uncompressed with the UNIX compress utility.
If you do not have gunzip, use the genesis.tar.Z file, instead.


August 11, 1995
===============

This directory now contains the 
August 1995 distribution of GENESIS, version 2.0.

Information about this new release is contained in the README file in this
directory.  Version 2.0 represents a major revision of GENESIS from the
previous version (1.4.2).  If you have used a previous version of GENESIS,
please read the file genesis/Doc/Changes.doc.  

This directory also contains the first release of Parallel GENESIS,
designed for networks of workstations (NOW), symmetric multiprocessors
(SMP) and massively parallel processors (MPP).  This release is known
to run on SGI/Irix and has run on these workstations: Sun4/Solaris,
Alpha/OSF1.3, DecStation/Ultrix4.3, Sun4/SunOS.  It has run on these
SMPs: SGI-Challenge/Irix 5.3, Sun4MP/Solaris.  It will soon be ported
to the Cray T3D/E MPP and later to Intel Paragon and IBM SP2 MPPs.

If you wish to compile the parallel libraries for GENESIS, you will need to
download the following files, in addition to the GENESIS 2.0 distribution:

        pargenesis.R1.tar.Z     - parlib source
        pvm3.3.6.tar.Z          - pvm3.3.6 source
        pvm_userguide.ps.Z      - pvm user's guide

For more information about GENESIS and "The Book of GENESIS", you may access
the GENESIS World Wide Web Server, http://www.bbb.caltech.edu/GENESIS.  This
will allow you to see "snapshots" of GENESIS simulations, take a look at the
manual, and find information about research which has been conducted with
GENESIS.